In the latest issue of Transplant International, Cortes Garcia and colleagues (France) examined bulk RNA sequencing of kidney biopsies. Most of the identified genes are included in the microarray and B-HOT panels, but the analysis also identified 603 (10%) and 1,186 (14%) novel genes associated with antibody-mediated rejection and T cell-mediated rejection, respectively. The microarray panel included metabolic functions and cell cycle progression processes, while the B-HOT panel correlated with key immunological processes involved in antibody-mediated rejection and T cell-mediated rejection. The newly identified genes could provide a new source of targets for drug design and repurposing.
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