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ENGAGE II – International Workshop on Immunomodulation and Desensitisation

Start Date:
Wednesday, November 27th 2024
End Date:
Thursday, November 28th 2024
Timezone:
CET
Country:
Barcelona, Spain
Description & Objectives:

The EuropeaN Guidelines for the mAnagement of Graft rEcipients (ENGAGE) is an initiative from the European Society for Organ Transplantation (ESOT).

ENGAGE II working group published an updated definition of sensitisation in candidates for solid organ transplantation (Bestard et al., Transpl Int, 2021, 34: 1005–1018) suggesting that data from the patient’s “immunological” history should be integrated with single-antigen bead assay and cytotoxic (CDC) and flow cytometry cross-matching to enable their risk of antibody-mediated rejection (AMR) and graft loss to be estimated and stratified into one of five categories. Building on this first step, the ENGAGE II working group performed a systematic search evaluating the Induction Therapies, Antibody Removal Strategies and New Biological Drugs and Maintenance immunosuppression, and these data have been synthesised in a white paper that has been the basis for the rationale of the following step, the ENGAGE consensus project.

The project, based on the Delphi methodology, was aimed at obtaining a consensus among European experts on desensitization and immunomodulation of kidney recipients, according to defined pre-transplantation patient humoral risk profiles. Desensitisation strategies are employed before the transplantation to prevent hyperacute rejection in patients with high levels of preformed DSA and, therefore, increase the transplant candidate’s access to transplantation. In contrast, the modulation of induction and maintenance immunosuppression (including the use of Antibody Removal Strategies) can be adjusted from day 0 onward according to the risk profile of the recipient in order to reduce his risk of subsequent AMR and graft loss.

The ENGAGE II working group final paper titled “European consensus on the management of sensitized kidney transplant recipients: a Delphi study” was accepted for publication on Transplant International (TI), in March 2024.

 

 

 

This project is possible thanks to unrestricted grants from Hansa.

 

Scientific Organising Committee
Lucrezia Furian (Italy)
Olivier Thaunat(France)
Oriol Bestard (Spain)
Georg Böhmig (Austria)
Emanuele Cozzi (Italy)
Maarten Naesens (Belgium)
Søren Schwartz Sørensen (Denmark)
Ondřej Viklický (Czech Republic)

Workshop Venue

Melia Sky Barcelona
Pere IV, 272 – 286
Barcelona

Project Coordinator

Supriya Barvesupriya.barve@esot.org

This project is possible thanks to unrestricted grants from Hansa.

 

Call for Applications

For this workshop, the scientific organising committee invites you to be part of the discussions on the outcomes of the ENGAGE II Project and participate in lively discussions on case studies surrounding immunomodulation and desensitisation.

If you wish to apply, please write to us at supriya.barve@esot.org, along with your CV.

The deadline is 10 October at 23:59 CEST.

Please note that there are only a limited number of seats available. We will contact you once the application is closed and we have made a selection.

Selected participants will have:

  • their travel covered for up to €500
  • a one-night stay, and the hotel venue