Liver transplantation in patients with PSC and IBD

In Europe, PSC is often associated to the presence of IBD and both disease influence reciprocally their pathophysiology. Additionally, an increased risk of colorectal and hepatobiliary malignancies in IBD and PSC respectively has been reported.

Although LT for PSC (+/- IBD) represents a standard indication, many questions remain unanswered, including:

• Pathophysiology, natural history and clinical aspects of PSC + IBD
• Surveillance strategies: focus on bile duct, liver and intestine
• Indication and timing of liver transplantation
• Management of bile duct stenosis on waiting list: diagnosis and treatment
• Technical aspects of liver transplantation
• Immunosuppression
• Prophylaxis and management of recurrent of PSC and IBD
• Timing and extension of intestinal resection (e.g. colectomy)

The main aim of this topic is to discuss the above concepts and to reach a final consensus, which is urgently needed.

Topic Chairs: Luca Belli & Silvio Nadalin

Topic Steering Committee: Marco Carbone, Chiara Mazzarelli, Andrea Della Penna, Eleonora De Martin, Annika Bergquist, Pal Dag Line, James Neuberger, Palak Trivedi