The aim of the Education Committee (EC) is to coordinate ESOT’s efforts to advance multidisciplinary education for transplant professionals at all career levels and to contribute to their professional development.
The Basic Science Committee promotes scientific issues and transplantation research within ESOT. An active basic science community and an efficient translation of innovation into the clinic are crucial for the future of transplantation medicine.
The European Transplant Allied Healthcare Professionals (ETAHP) reaches out to allied healthcare professionals throughout Europe in order to ensure the best care possible for all transplant patients, with the aim to optimize patient outcomes.
The Young Professionals in Transplantation (YPT) is the Network for Junior Transplant professionals of ESOT, representing all young transplant clinicians and scientists who are beginning a career in transplantation and organ donation.
The mission of ECTORS is to provide a forum for discussing and stimulating novel developments in the fields of cellular therapies in organ transplantation, organ regeneration and generation of new organs from stem cells and biomaterials.
ECTTA is the forum for experience exchange on treatment of patients with end-stage heart and lung failure. Our aim is to improve outcomes for the patients.
EDTCO aims to support health care professionals to provide clinically effective programmes on organ and tissue donation, procurement and transplantation.
EKITA is the Organ Expert Section of ESOT on kidney transplantation in Europe, providing a forum for kidney transplantation professionals to exchange scientific information and views aimed at providing the best service to European patients .
The European Liver and Intestine Transplant Association (ELITA), previously known as the European Liver Transplant Association (ELTA), is a section of ESOT. Its membership represents the expertise on liver and intestinal transplantation in Europe.
ELPAT is a European platform that brings continuity and progress in European research and dialogue on "Ethical, Legal and Psychosocial Aspects of organ Transplantation". ELPAT currently consists of over 160 experts from more than 25 European countries.
EPITA is established to provide a forum for those working in the field of pancreas and islet of Langerhans transplantation or any other alternative form of beta cell replacement in Europe, to exchange scientific information and views related primarily to providing the best service for patients in Europe requiring pancreas or islet transplantation.
VCA has opened a new era in the field of transplantation, reconstructive and restorative surgery. This Section brings together 10 representatives of major European teams at the forefront in this field.
We will discuss the last article on dd-cfDNA bit.ly/47ABImn
Elevated dd-cfDNA levels reflect allograft damage, and studies have shown that dd-cfDNA can distinguish active rejection from no rejection. In this prospective study, the objective was to analyze dd-cfDNA within a group of German kidney transplant recipients.
106 kidney transplant recipients with a total of 108 graft biopsies were enrolled. Of the 108 allograft biopsies, 36 (33%) were classified as different types of rejection, where of 7 biopsies were graded as ABMR, 6 as TCMR, and 23 as borderline changes.
Patients with histopathological signs of active rejection had significantly higher levels of dd-cfDNA at time of biopsy than patients without signs for rejection, whereas estimated glomerular filtration rate (eGFR) did not differ significantly between the two groups.
dd-cfDNA levels were with a median (IQR) % of 2.00 (0.48–3.20) highest in patients with ABMR, followed by 0.92 (0.19–11.25) in patients with TCMR, 0.44 (0.20–1.10) in patients with borderline changes and 0.20 (0.11–0.53) in patients with no signs of rejection.
The AUC to discriminate any type of rejection including borderline changes from no rejection was at 0.72 (95% CI 0.62–0.83). For the discrimination of only ABMR or only TCMR from no rejection, dd-cfDNA exhibited an AUC of 0.90 (95% CI 0.78–1.00) and 0.73 (95% CI 0.47–0.99).
The optimal cut point for dd-cfDNA to discriminate active rejection from no rejection was at a threshold of 0.57, yielding a specificity of 81% (95% CI 70%–88%), a sensitivity of 53% (95% CI 37%–68%), a PPV of 58% (95% CI 41%–73%), and an NPV of 77% (95% CI 67%–85%).
